Subscribe free to our newsletters via your
. GPS News .




EPIDEMICS
Researchers find HIV's 'invisibility cloak'
by Staff Writers
Paris (AFP) Nov 06, 2013


Scientists said Wednesday they had found an "invisibility cloak" that allows the AIDS virus to lurk unnoticed in human cells after infection and replicate without triggering the immune system.

And they managed to "uncloak" the virus with an experimental drug in lab-grown cells -- a feat that may lead to new and better HIV treatments, the team wrote in the journal Nature.

"The hope is that one day we may be able to develop a treatment that helps the body to clear the virus before the infection is able to take hold," the study's lead author Greg Towers of the University College London said in a statement by the Wellcome Trust, which co-funded the study.

The body's immune system is the first line of defence against infection, with an "alarm system" in each cell for detecting invading bacteria or viruses.

When the alarm is triggered, the cell activates an anti-viral response and alerts surrounding cells, which do the same.

But the human immunodeficiency virus (HIV) infects vital white blood cells of the immune system and replicates undetected for a while before triggering the alarm system -- a trait that scientists have battled to understand.

"HIV is extremely adept at hiding from our body's natural defences, which is part of the reason the virus is so dangerous," said Towers.

"Now we've identified the virus' invisibility cloak and how to expose it, we've uncovered a weakness that could be exploited for new HIV treatments."

Towers and a team identified two molecules inside human cells that are "recruited" by HIV after infection to help shield it and thus delay the immune response.

They then administered an experimental drug, based on Cyclosporine, which is widely used to prevent organ rejection in transplant patients because it dampens the immune system, according to the statement.

The drug prevented the virus using the molecules as a cloak, they found.

"The team used a modified version of the drug, which blocks the effects of the two cloaking molecules without suppressing immune activity," said the statement.

HIV is a retrovirus, inserting its DNA into the genome of CD4+T cells and turning them into virus factories.

Some 35.3 million people around the world are living with HIV, which destroys the immune system and has caused more than 25 million deaths since AIDS first emerged in the early 1980s, according to the World Health Organisation.

Existing treatments help infected people live longer, healthier lives but do not cure AIDS. Many people in poor communities do not have access to the life-giving drugs, and there is no vaccine.

.


Related Links
Epidemics on Earth - Bird Flu, HIV/AIDS, Ebola






Comment on this article via your Facebook, Yahoo, AOL, Hotmail login.

Share this article via these popular social media networks
del.icio.usdel.icio.us DiggDigg RedditReddit GoogleGoogle








EPIDEMICS
Breakthrough in hunt for HIV vaccine
Washington (AFP) Nov 01, 2013
US scientists seeking to unravel the mysteries of HIV have made an important breakthrough after capturing the clearest image yet of a protein which allows the deadly virus to attack human immune cells, new research showed Tuesday. Scientists at The Scripps Research Institute (TSRI) and Weill Cornell Medical College have managed to obtain a detailed view of the atomic structure of the protein ... read more


EPIDEMICS
China exchange hatches plan for egg futures

Warsaw climate meet must measure rich lands' emissions

We'll rise or fall on the quality of our soil

EU faces decision on GM crop cultivation: Commission

EPIDEMICS
Nanoscale engineering boosts performance of quantum dot light emitting diodes

JQI team 'gets the edge' on photon transport in silicon

Atomically Thin Device Promises New Class of Electronics

Tiny Sensors Put the Squeeze on Light

EPIDEMICS
Seoul eyes export market for its Surion light helicopter

Declassified: USAF tested secretly acquired Soviet fighters in Area 51

El Salvador to buy used attack planes from Chile

New Climate-studying Imager Makes First Balloon Flight

EPIDEMICS
The end of traffic jams? Dutch test new system

Japanese automakers step on profit accelerator

Toyota to unveil concept fuel-cell car at Tokyo Motor Show

France backs down on truck 'ecotax' after protests

EPIDEMICS
Myanmar military launches investor charm offensive

IBM says will 'aggressively' contest India tax demand

Major China trade fair export orders hit four-year low

Australia's mining boom over: report

EPIDEMICS
China slaps dumping penalties on pulp imports

Warm winters let trees sleep longer

Study of Brazilian Amazon shows 50,000 km of road was built in just three years

Local communities produce high-quality forest monitoring data, rivals that of professional foresters

EPIDEMICS
Sensor Payloads Lift Off With Availability of Complete Hyperspectral Airborne Solution

Seeing in the dark

Researchers Turn to Technology to Discover a Novel Way of Mapping Landscapes

Astrium partners with information and analytics specialist IHS to support GEOINT community

EPIDEMICS
Scientists untangle nanotubes to release their potential in the electronics industry

Nano-Cone Textures Generate Extremely "Robust" Water-Repellent Surfaces

Newly discovered mechanism propels micromotors

Densest array of carbon nanotubes grown to date




The content herein, unless otherwise known to be public domain, are Copyright 1995-2014 - Space Media Network. AFP, UPI and IANS news wire stories are copyright Agence France-Presse, United Press International and Indo-Asia News Service. ESA Portal Reports are copyright European Space Agency. All NASA sourced material is public domain. Additional copyrights may apply in whole or part to other bona fide parties. Advertising does not imply endorsement,agreement or approval of any opinions, statements or information provided by Space Media Network on any Web page published or hosted by Space Media Network. Privacy Statement